In the treaty that concluded the War of the League of Cognac in
June, Charles V pledged to restore and uphold the rule of the
Medici in Florence. However, the family now encounter popular
opposition to their restoration, which has established itself as a
republic, and an imperial army is forced to lay siege to the city
until August 1530 to achieve success.
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Editors. "Opposition to the restoration of the Medici in Florence". The Literary Encyclopedia. First published 01 November 2010
[https://www.litencyc.com/php/stopics.php?rec=true&UID=14435, accessed 19 November 2017.]