French and Swiss armies meet at the Battle of Marignano. In a turning-point after years of Swiss successes in northern Italy, the young Francis I (he had just turned 21 at the time of the battle), with an arsenal of powerful artillery, defeats the famous Swiss infantrymen and conquers Milan.
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Editors. "France invades Italy". The Literary Encyclopedia. First published 01 March 2010
[https://www.litencyc.com/php/stopics.php?rec=true&UID=9917, accessed 18 February 2018.]