French and Swiss armies meet at the Battle of Marignano. In a turning-point after years of Swiss successes in northern Italy, the young Francis I (he had just turned 21 at the time of the battle), with an arsenal of powerful artillery, defeats the famous Swiss infantrymen and conquers Milan.
Editors. "France invades Italy". The Literary Encyclopedia. First published 01 March 2010
[http://www.litencyc.com/php/stopics.php?rec=true&UID=9917, accessed 22 May 2013.]